tert-Butyl 1,6-diazaspiro[3.5]nonane-1-carboxylate

Name: tert-Butyl 1,6-diazaspiro[3.5]nonane-1-carboxylate
Brand: ChemScene
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CAS No. 1251005-45-4
Cat. No. CS-0048491
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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tert-Butyl 1,6-diazaspiro[3.5]nonane-1-carboxylate|CS-0048491

Structure of 1251005-45-4

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Description

tert-Butyl 1,6-diazaspiro[3.5]nonane-1-carboxylate features a rigid spirocyclic scaffold with two nitrogen atoms at the 1- and 6-positions, offering enhanced conformational control. The tert-butyl ester group provides stability and ease of handling, enabling straightforward deprotection under mild acidic conditions. This compound serves as a valuable building block in medicinal chemistry for constructing constrained heterocyclic motifs.

Application

tert-Butyl 1,6-diazaspiro[3.5]nonane-1-carboxylate serves as a versatile scaffold for constructing spirocyclic amine libraries, enabling efficient access to constrained piperazine analogs. The tert-butyl carbamate group offers excellent bench stability and facilitates straightforward deprotection under mild acidic conditions. Its dual nitrogen atoms provide orthogonal reactivity for selective functionalization, making it well-suited for medicinal chemistry campaigns targeting CNS-directed therapeutics and kinase inhibitors.

General Information

CAS No. 1251005-45-4
Cat. No. CS-0048491
Purity ≥97%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₂H₂₂N₂O₂
Molecular Weight 226.32
Synonym(s) 1-Boc-1,6-diaza-spiro[3.5]nonane
SMILES CC(C)(C)OC(=O)N1CCC11CCCNC1

Computational Chemistry Data

TPSA 41.57
LogP 1.7494
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Building Blocks Skeleton Aliphatic heterocycle compounds Azetidine compounds

Building Blocks Skeleton Spirol Rings compounds

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tert-Butyl 1,6-diazaspiro[3.5]nonane-1-carboxylate

CAS No. 1251005-45-4

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