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CS-W001157 4
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7-Bromo-2-chloro-1H-benzo[d]imidazole

  • CAS No. 1248548-54-0

  • Cat. No. CS-0375933
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

7-Bromo-2-chloro-1H-benzo[d]imidazole|CS-0375933

Structure of 1248548-54-0

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General Information

  • CAS No. 1248548-54-0
  • Cat. No. CS-0375933
  • Purity ≥96%
  • MDL No. None
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₄BrClN₂
  • Molecular Weight 231.48
  • Synonym(s) 4-Bromo-2-chloro-1H-benzo[d]imidazole
  • SMILES ClC1=NC2=CC=CC(Br)=C2N1

Description

7-Bromo-2-chloro-1H-benzo[d]imidazole features a fused heterocyclic core with complementary halogen substituents enabling precise functionalization. The bromine and chlorine atoms facilitate palladium-catalyzed cross-coupling reactions, while the electron-deficient imidazole ring enhances reactivity in C–H activation and transition-metal-mediated transformations. This scaffold serves as a robust building block for bioactive molecules and advanced materials.

Application

7-Bromo-2-chloro-1H-benzo[d]imidazole serves as a versatile heterocyclic building block in medicinal chemistry and materials science. Its dual halogenation pattern enables palladium-catalyzed cross-coupling reactions, including Suzuki-Miyaura and Buchwald-Hartwig aminations, with high functional group tolerance. The molecule exhibits excellent bench stability and facilitates efficient purification, making it well-suited for modular synthesis of biologically active scaffolds and advanced organic semiconductors.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H320-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   28.68
  • LogP   2.9788
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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