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CS-W001157 4
Total: USD 88.00

4-Fluorobenzo[d]thiazole

  • CAS No. 1247348-92-0

  • Cat. No. CS-0132106
  • Molecule weight153.18
  • Purity≥95%
  • MDL No.MFCD17014583

*For research and further manufacturing use only, not for direct human use.

4-Fluorobenzo[d]thiazole|CS-0132106

Structure of 1247348-92-0

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General Information

  • CAS No. 1247348-92-0
  • Cat. No. CS-0132106
  • Purity ≥95%
  • MDL No. MFCD17014583
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₄FNS
  • Molecular Weight 153.18
  • Synonym(s) 4-Fluorobenzthiazol
  • SMILES FC1=C2N=CSC2=CC=C1

Description

4-Fluorobenzo[d]thiazole features a fluorinated benzene ring fused to a thiazole heterocycle, delivering enhanced electronic properties and metabolic stability. This scaffold integrates readily into bioactive molecules, serving as a key pharmacophore in medicinal chemistry. The electron-withdrawing fluorine modulates reactivity and improves membrane permeability, enabling efficient incorporation into drug candidates and functional materials.

Application

4-Fluorobenzo[d]thiazole serves as a versatile heterocyclic building block in medicinal chemistry and materials science, enabling efficient transition-metal-catalyzed coupling reactions. Its fluorinated aromatic ring enhances metabolic stability and modulates electronic properties, while the thiazole core provides a rigid, polar scaffold with favorable solubility and functional group tolerance. The compound exhibits excellent bench stability and facilitates straightforward purification, making it ideal for use in parallel synthesis campaigns and API intermediate development.

Synthesis

  • Route1

    References

    • SANOFI Patent: US2012/95040 A1, 2012 ; Location in patent: Page/Page column 14 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.4354
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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