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CS-W001157 4
Total: USD 88.00

2-Methoxy-4-methoxycarbonyl-phenyl-boronic acid pinacol ester

  • CAS No. 1246765-32-1

  • Cat. No. CS-0340452
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Methoxy-4-methoxycarbonyl-phenyl-boronic acid pinacol ester|CS-0340452

Structure of 1246765-32-1

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General Information

  • CAS No. 1246765-32-1
  • Cat. No. CS-0340452
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₅H₂₁BO₅
  • Molecular Weight 292.14
  • Synonym(s) Methyl 3-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate
  • SMILES CC1(C)C(C)(C)OB(C2=C(C=C(C=C2)C(=O)OC)OC)O1

Description

This boronate ester features a methoxy-substituted aryl core paired with a methoxycarbonyl group, enhancing solubility and stability. The pinacol protection delivers bench-stable handling while enabling efficient Suzuki-Miyaura coupling under standard conditions. Ideal for constructing complex phenyl scaffolds in medicinal chemistry and materials synthesis.

Application

2-Methoxy-4-methoxycarbonyl-phenyl-boronic acid pinacol ester serves as a stable, bench-ready building block for Suzuki-Miyaura cross-coupling reactions. Its ortho-methoxy and meta-methoxycarbonyl substituents provide enhanced solubility and functional group tolerance, enabling efficient C–C bond formation under mild conditions. The pinacol boronate ester resists protodeboronation and simplifies purification, making it ideal for constructing complex aryl scaffolds in medicinal chemistry and materials science workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H332
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

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Computational Chemistry Data

  • TPSA   53.99
  • LogP   1.781
  • H_Acceptors   5
  • H_Donors   0
  • Rotatable_Bonds   3

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