(3R)-3-Amino-2,3-dihydro-1H-indene-5-carboxylic acid methyl ester hydrochloride

Name: (3R)-3-Amino-2,3-dihydro-1H-indene-5-carboxylic acid methyl ester hydrochloride
Brand: ChemScene
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CAS No. 1246509-67-0
Cat. No. CS-0105033
Purity≥95%
MDL No.MFCD22392685

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(3R)-3-Amino-2,3-dihydro-1H-indene-5-carboxylic acid methyl ester hydrochloride|CS-0105033

Structure of 1246509-67-0

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Description

This chiral indene derivative features a bench-stable, moisture-tolerant methyl ester group and a protonated amine, enabling straightforward coupling and derivatization. The (3R) configuration ensures high stereochemical fidelity in asymmetric synthesis, while the para-carboxylate functionality facilitates conjugation and solubility optimization in biopharmaceutical workflows.

Application

(3R)-3-Amino-2,3-dihydro-1H-indene-5-carboxylic acid methyl ester hydrochloride serves as a stereochemically defined building block for indoline-based scaffolds. The chiral center at C3 ensures high enantioselectivity in downstream transformations, while the amino and ester functionalities enable sequential derivatization—facilitating amide coupling, reductive amination, or cyclization reactions. Bench-stable and readily purified by standard techniques, it functions effectively in medicinal chemistry campaigns targeting CNS-active compounds and kinase inhibitors.

General Information

CAS No. 1246509-67-0
Cat. No. CS-0105033
Purity ≥95%
MDL No. MFCD22392685
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₁H₁₄ClNO₂
Molecular Weight 227.69
Synonym(s) (R)-methyl 3-amino-2,3-dihydro-1H-indene-5-carboxylate hydrochloride
SMILES O=C(C1=CC2=C(CC[C@H]2N)C=C1)OC.[H]Cl

Computational Chemistry Data

TPSA 52.32
LogP 1.841
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Ester

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

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(3R)-3-Amino-2,3-dihydro-1H-indene-5-carboxylic acid methyl ester hydrochloride

CAS No. 1246509-67-0

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