7-Bromo-3-iodoimidazo[1,2-a]pyridine

Name: 7-Bromo-3-iodoimidazo[1,2-a]pyridine
Brand: ChemScene
Availability: InStock
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CAS No. 1246184-55-3
Cat. No. CS-0056569
Purity≥96%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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7-Bromo-3-iodoimidazo[1,2-a]pyridine|CS-0056569

Structure of 1246184-55-3

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General Information

CAS No. 1246184-55-3
Cat. No. CS-0056569
Purity ≥96%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₄BrIN₂
Molecular Weight 322.93
Synonym(s) 7-BroMo-3-iodo-iMidazo[1,2-a]pyridine
SMILES IC1=CN=C2C=C(Br)C=CN21

Description

7-Bromo-3-iodoimidazo[1,2-a]pyridine features a dual halogenated imidazopyridine core, enabling efficient cross-coupling reactions in medicinal chemistry. The electron-deficient aromatic system pairs well with palladium catalysts, while the bromo and iodo substituents offer orthogonal reactivity for sequential functionalization. This scaffold supports rapid diversification in target-oriented synthesis.

Application

7-Bromo-3-iodoimidazo[1,2-a]pyridine serves as a versatile bifunctional building block for the construction of imidazo[1,2-a]pyridine scaffolds in medicinal chemistry and catalytic synthesis. The bromo and iodo substituents enable sequential cross-coupling reactions with high chemoselectivity, facilitating access to complex heterocyclic architectures. Its bench-stable nature and compatibility with palladium-catalyzed coupling protocols make it well-suited for iterative functionalization in API development workflows.

Synthesis

Route1
- In-stock
  
  808744-34-5
- ~%
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  1246184-55-3
References
- WO2010/108074 A2, ; Page/Page column 63 ; WO 2010/108074 A2

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 17.3
LogP 2.7014
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Imidazole compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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7-Bromo-3-iodoimidazo[1,2-a]pyridine

CAS No. 1246184-55-3

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