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Structure of 1242339-67-8
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2-Chloro-4,6-difluorobenzoic acid features a trifluorinated aromatic core with orthogonal halogen substituents enabling selective cross-coupling. The carboxylic acid group provides a robust handle for amide bond formation and derivatization under standard conditions. This configuration delivers enhanced metabolic stability and electron-withdrawing character, ideal for pharmaceutical intermediates and agrochemical scaffold development.
2-Chloro-4,6-difluorobenzoic acid serves as a versatile building block in medicinal chemistry and agrochemical synthesis. Its electron-deficient aromatic core enables efficient coupling reactions, particularly in Suzuki-Miyaura and Buchwald-Hartwig protocols. The carboxylic acid group facilitates direct derivatization to amides, esters, or acyl chlorides, while the ortho-chloro and meta-fluoro substituents provide orthogonal reactivity for selective functionalization. Bench-stable and readily purified by recrystallization, it functions reliably in multi-step syntheses of bioactive heterocycles and API intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: