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CS-W001157 4
Total: USD 88.00

5-Chloro-4-fluoro-2-methylaniline

  • CAS No. 1242339-43-0

  • Cat. No. CS-0061250
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Chloro-4-fluoro-2-methylaniline|CS-0061250

Structure of 1242339-43-0

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General Information

  • CAS No. 1242339-43-0
  • Cat. No. CS-0061250
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇ClFN
  • Molecular Weight 159.59
  • Synonym(s) None
  • SMILES CC1=CC(=C(C=C1N)Cl)F

Description

5-Chloro-4-fluoro-2-methylaniline features a trifunctional aromatic core with chlorine, fluorine, and methyl groups positioned for orthogonal reactivity. This electron-deficient aniline derivative enables selective coupling in pharmaceutical intermediates and advanced materials synthesis under standard conditions.

Application

5-Chloro-4-fluoro-2-methylaniline serves as a versatile building block for the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its ortho-methyl group enhances metabolic stability, while the strategically positioned chloro and fluoro substituents enable directed metallation and subsequent functionalization. The compound exhibits excellent bench stability and compatibility with standard coupling reactions, facilitating efficient access to complex scaffolds in medicinal chemistry workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   2.36972
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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