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CS-W001157 4
Total: USD 88.00

4-Bromo-2-fluoronicotinonitrile

  • CAS No. 1240620-65-8

  • Cat. No. CS-0700590
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-Bromo-2-fluoronicotinonitrile|CS-0700590

Structure of 1240620-65-8

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General Information

  • CAS No. 1240620-65-8
  • Cat. No. CS-0700590
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₂BrFN₂
  • Molecular Weight 201.00
  • Synonym(s) None
  • SMILES FC1=NC=CC(Br)=C1C#N

Description

4-Bromo-2-fluoronicotinonitrile is a fluorinated nitrile-containing heterocycle featuring complementary halogen and cyano functionalities. This electron-deficient pyridine derivative enables direct coupling in cross-coupling reactions and serves as a key building block for pharmaceutical intermediates and functional materials.

Application

4-Bromo-2-fluoronicotinonitrile serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through palladium-catalyzed cross-coupling and nucleophilic substitution reactions. Its orthogonal reactivity—combining a bromide for coupling and a nitrile for functionalization—facilitates rapid diversification of pyridine-based scaffolds. The molecule exhibits excellent bench stability and compatibility with standard synthetic protocols, supporting efficient late-stage modifications in API development workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 3439
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H311-H331
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P405-P501

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Computational Chemistry Data

  • TPSA   36.68
  • LogP   1.85488
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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