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CS-W001157 4
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4-Bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid

  • CAS No. 1234616-71-7

  • Cat. No. CS-0163672
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-Bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid|CS-0163672

Structure of 1234616-71-7

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General Information

  • CAS No. 1234616-71-7
  • Cat. No. CS-0163672
  • Purity ≥97%
  • MDL No. None
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅BrN₂O₂
  • Molecular Weight 241.04
  • Synonym(s) None
  • SMILES O=C(C1=CC2=C(Br)C=CN=C2N1)O

Description

This pyrrolopyridine carboxylic acid features a brominated heterocyclic core with a pendant carboxylic acid group, enabling direct incorporation into bioactive scaffolds. The electron-deficient ring system facilitates cross-coupling reactions, while the carboxylic acid serves as a handle for derivatization. Bench-stable and moisture-tolerant, it supports efficient synthesis in medicinal chemistry workflows.

Application

4-Bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling direct incorporation into heterocyclic scaffolds via cross-coupling and functional group transformations. The carboxylic acid moiety facilitates derivatization through amide formation or esterification, while the bromine substituent supports palladium-catalyzed coupling reactions. Bench-stable and compatible with standard purification methods, it functions effectively in the synthesis of kinase inhibitors and other bioactive molecules.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   65.98
  • LogP   2.0236
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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