1H-Pyrazolo[3,4-b]pyridine-5-carbonitrile

Name: 1H-Pyrazolo[3,4-b]pyridine-5-carbonitrile
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1234616-67-1
Cat. No. CS-W007040
Purity≥98%
MDL No.None

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

1H-Pyrazolo[3,4-b]pyridine-5-carbonitrile|CS-W007040

Structure of 1234616-67-1

Size

Price

Quantity

* Please select Quantity before adding items.

Description

1H-Pyrazolo[3,4-b]pyridine-5-carbonitrile is a heterocyclic scaffold featuring a fused pyrazole-pyridine core with a nitrile group at the 5-position. This electron-deficient system enables efficient coupling in transition-metal-catalyzed reactions and serves as a key building block for bioactive molecule synthesis. The nitrile moiety enhances molecular polarity and provides a handle for derivatization.

Application

1H-Pyrazolo[3,4-b]pyridine-5-carbonitrile serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to fused pyrazolopyridine scaffolds. Its nitrile group facilitates downstream functionalization via hydrolysis, nucleophilic addition, or coupling reactions, while the core structure exhibits good bench stability and compatibility with standard synthetic protocols. Functions effectively in transition-metal-catalyzed cross-couplings and serves as a key intermediate in the development of kinase inhibitors and other bioactive molecules.

General Information

CAS No. 1234616-67-1
Cat. No. CS-W007040
Purity ≥98%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₄N₄
Molecular Weight 144.13
Synonym(s) (E)-tert-Butyl 5-(3-methoxy-3-oxoprop-1-en-1-yl)-1H-pyrazolo[3,4-b]pyridine-1-carboxylate
SMILES N#CC1=CN=C(NN=C2)C2=C1

Computational Chemistry Data

TPSA 65.36
LogP 0.82958
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyrazole compounds

Drug Discovery Inflammation/Immunology IRAK4

Key Words

1234616-67-1 sigma1234616-67-1 manufacturer1234616-67-1 price1234616-67-1 structure1234616-67-1 SDSbuy 1234616-67-11234616-67-1 supplier1234616-67-1 uses1234616-67-1 molecular weightprice of 1234616-67-11234616-67-1 chemical name formula of 1234616-67-1

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

1H-Pyrazolo[3,4-b]pyridine-5-carbonitrile

CAS No. 1234616-67-1

Recommended Products