1H-Pyrrolo[2,3-b]pyridine, 4-bromo-1-methyl-

Name: 1H-Pyrrolo[2,3-b]pyridine, 4-bromo-1-methyl-
Brand: ChemScene
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CAS No. 1234616-25-1
Cat. No. CS-0030464
Purity≥95%
MDL No.None

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FedEx Limited Quantities Ground	$0.00
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1H-Pyrrolo[2,3-b]pyridine, 4-bromo-1-methyl-|CS-0030464

Structure of 1234616-25-1

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General Information

CAS No. 1234616-25-1
Cat. No. CS-0030464
Purity ≥95%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₇BrN₂
Molecular Weight 211.06
Synonym(s) 4-Bromo-1-methyl-pyrrolo[2,3-b]pyridine
SMILES CN1C=CC2=C(Br)C=CN=C21

Description

4-Bromo-1-methyl-1H-pyrrolo[2,3-b]pyridine is a heteroaromatic building block featuring a brominated pyrrolopyridine core with a methyl substituent at the nitrogen. This electron-deficient scaffold enables direct functionalization in cross-coupling reactions and serves as a key intermediate in the synthesis of bioactive compounds and advanced materials.

Application

4-Bromo-1-methyl-1H-pyrrolo[2,3-b]pyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its well-defined bromo functionality. The methyl group enhances solubility and stability, while the fused heterocyclic core provides a rigid scaffold suitable for drug discovery applications. Its bench-stable nature and compatibility with standard reaction conditions facilitate efficient synthesis of complex nitrogen-containing architectures.

Synthesis

Route1
- 74-88-4
- In-stock
  
  348640-06-2
- ~%
- In-stock
  
  1234616-25-1
References
- Tsou, Hwei-Ru; MacEwan, Gloria; Birnberg, Gary; Grosu, George; Bursavich, Matthew G.; Bard, Joel; Brooijmans, Natasja; Toral-Barza, Lourdes; Hollander, Irwin; Mansour, Tarek S.; Ayral-Kaloustian, Semiramis; Yu, Ker Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 7 p. 2321 - 2325

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 17.82
LogP 2.3358
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyrrole compounds

Key Words

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1H-Pyrrolo[2,3-b]pyridine, 4-bromo-1-methyl-

CAS No. 1234616-25-1

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