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Structure of 123387-50-8
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tert-Butyl 4-methylpiperidine-1-carboxylate serves as a protected piperidine scaffold with enhanced stability and solubility. The tert-butyl carbamate group enables convenient deprotection under mild acidic conditions, while the 4-methyl substitution provides steric shielding and modulates basicity. This derivative integrates readily into medicinal chemistry libraries for targeted optimization of pharmacokinetic properties.
tert-Butyl 4-methylpiperidine-1-carboxylate serves as a versatile building block in medicinal chemistry, enabling efficient access to piperidine-based scaffolds. The tert-butyl carbamate group provides excellent bench stability and facile deprotection under mild acidic conditions, while the 4-methyl substitution enhances conformational rigidity and modulates basicity. It functions reliably in reductive amination, alkylation, and transition-metal-catalyzed coupling reactions, supporting diverse functionalization strategies for drug discovery applications.
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GHS Pictogram :
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GHS No : GHS06,GHS09
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Signal Word : Danger
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UN#: 2810
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H227-H301-H315-H319-H335-H410
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Precautionary Statements : P210-P261-P264-P270-P271-P273-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P370+P378-P391-P403-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: