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CS-W001157 4
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5-Bromo-2-methoxypyridin-4-amine

  • CAS No. 1232431-48-9

  • Cat. No. CS-0050616
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Bromo-2-methoxypyridin-4-amine|CS-0050616

Structure of 1232431-48-9

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General Information

  • CAS No. 1232431-48-9
  • Cat. No. CS-0050616
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇BrN₂O
  • Molecular Weight 203.04
  • Synonym(s) ethyl(3R)-piperidine-5-carboxylate
  • SMILES COC1=NC=C(Br)C(N)=C1

Description

5-Bromo-2-methoxypyridin-4-amine features a pyridine core functionalized with bromo, methoxy, and amino groups at strategic positions. This trifunctional scaffold enables direct coupling in cross-coupling reactions and serves as a key intermediate in the synthesis of bioactive heterocycles. The electron-rich pyridine ring enhances reactivity in palladium-catalyzed transformations.

Application

5-Bromo-2-methoxypyridin-4-amine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its well-defined bromine handle. The methoxy group enhances solubility and modulates electronic properties, while the pyridin-4-amine functionality provides a robust site for further derivatization. This compound exhibits excellent bench stability and facilitates efficient purification, making it ideal for iterative synthesis campaigns targeting heterocyclic scaffolds and API intermediates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   48.14
  • LogP   1.4349
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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