5-Bromo-4-methoxypyridin-2-amine

Name: 5-Bromo-4-methoxypyridin-2-amine
Brand: ChemScene
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CAS No. 1232431-11-6
Cat. No. CS-0043022
Purity≥95%
MDL No.MFCD15143383

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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5-Bromo-4-methoxypyridin-2-amine|CS-0043022

Structure of 1232431-11-6

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Description

5-Bromo-4-methoxypyridin-2-amine features a pyridine core functionalized with bromo and methoxy groups at positions 5 and 4, respectively, and an amino group at C2. This electron-deficient heterocycle integrates readily into cross-coupling reactions, serving as a key intermediate in the synthesis of bioactive compounds and pharmaceuticals.

Application

5-Bromo-4-methoxypyridin-2-amine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its well-defined electrophilic bromine site. The methoxy group enhances solubility and modulates electronic properties, while the pyridin-2-amine functionality provides a handle for further derivatization via amidation or metal coordination. Its bench-stable nature and compatibility with standard synthetic protocols make it ideal for constructing heterocyclic scaffolds in API development.

General Information

CAS No. 1232431-11-6
Cat. No. CS-0043022
Purity ≥95%
MDL No. MFCD15143383
Storage RT, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₇BrN₂O
Molecular Weight 203.04
Synonym(s) 2-Amino-5-bromo-4-methoxypyridine
SMILES NC1=NC=C(Br)C(OC)=C1

Computational Chemistry Data

TPSA 48.14
LogP 1.4349
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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5-Bromo-4-methoxypyridin-2-amine

CAS No. 1232431-11-6

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