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Methyl 2-(2-chloropyridin-3-yl)acetate

  • CAS No. 123222-09-3

  • Cat. No. CS-0312351
  • Purity≥97%
  • MDL No.MFCD20277938

*For research and further manufacturing use only, not for direct human use.

Methyl 2-(2-chloropyridin-3-yl)acetate|CS-0312351

Structure of 123222-09-3

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General Information

  • CAS No. 123222-09-3
  • Cat. No. CS-0312351
  • Purity ≥97%
  • MDL No. MFCD20277938
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈ClNO₂
  • Molecular Weight 185.61
  • Synonym(s) 3-Pyridineacetic acid, 2-chloro-, methyl ester
  • SMILES O=C(CC1=CC=CN=C1Cl)OC

Description

Methyl 2-(2-chloropyridin-3-yl)acetate features a chloropyridine moiety linked to a methyl ester-functionalized acetyl group, enabling direct incorporation into heterocyclic synthesis. The electron-deficient pyridine ring enhances reactivity in nucleophilic substitution and coupling processes, while the ester handle supports further derivatization. This bench-stable compound serves as a key intermediate for pharmaceutical and agrochemical scaffolds.

Application

Methyl 2-(2-chloropyridin-3-yl)acetate serves as a versatile building block in medicinal chemistry, enabling efficient access to pyridine-containing scaffolds via palladium-catalyzed cross-coupling reactions. The ortho-chloropyridine moiety facilitates direct functionalization, while the ester group offers compatibility with reduction, hydrolysis, and further derivatization. Its bench-stable, crystalline nature supports straightforward handling and purification, making it well-suited for iterative synthesis campaigns and API intermediate development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   39.19
  • LogP   1.4505
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   2

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