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CS-W001157 4
Total: USD 88.00

(αS)-4-Bromo-2-fluoro-α-methylbenzenemethanamine

  • CAS No. 1228559-00-9

  • Cat. No. CS-0653354
  • Purity≥98%
  • MDL No.None
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

(αS)-4-Bromo-2-fluoro-α-methylbenzenemethanamine|CS-0653354

Structure of 1228559-00-9

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Description

This chiral amine features a strategically positioned bromine and fluorine substituent on the aromatic ring, enabling selective functionalization in medicinal chemistry. The α-methyl group imparts stereochemical stability, while the amine handle facilitates conjugation in target-directed synthesis.

Application

(αS)-4-Bromo-2-fluoro-α-methylbenzenemethanamine serves as a valuable chiral building block for the synthesis of bioactive molecules, enabling stereoselective incorporation of fluorinated aryl motifs. Its functional group tolerance facilitates downstream coupling reactions, while the α-methyl substitution enhances metabolic stability. The compound exhibits good bench stability and is readily purified by standard chromatographic methods, making it well-suited for medicinal chemistry campaigns requiring fluorinated phenylalanine analogs.

General Information

  • CAS No. 1228559-00-9
  • Cat. No. CS-0653354
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉BrFN
  • Molecular Weight 218.07
  • Synonym(s) None
  • SMILES C[C@@H](C1=C(C=C(C=C1)Br)F)N

Computational Chemistry Data

  • TPSA   26.02
  • LogP   2.6079
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group :
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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