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Structure of 1227603-09-9
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3-Methoxy-5-(trifluoromethyl)pyridin-2-amine features a trifluoromethyl group that enhances metabolic stability and electron-withdrawing character, while the methoxy substituent provides solubility and directional control in cross-coupling reactions. This pyridine scaffold integrates readily into bioactive molecules and serves as a key intermediate in pharmaceutical development.
3-Methoxy-5-(trifluoromethyl)pyridin-2-amine serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyridine-based scaffolds. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the methoxy and primary amine functionalities offer orthogonal handles for further derivatization. The compound exhibits good bench stability and facilitates diverse coupling reactions, including Suzuki-Miyaura and Buchwald-Hartwig protocols, making it well-suited for API development and high-throughput synthesis workflows.
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: