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(3,6-Dibromopyridin-2-yl)methanol

  • CAS No. 1227601-31-1

  • Cat. No. CS-0162322
  • Purity≥98%
  • MDL No.MFCD16606961

*For research and further manufacturing use only, not for direct human use.

(3,6-Dibromopyridin-2-yl)methanol|CS-0162322

Structure of 1227601-31-1

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General Information

  • CAS No. 1227601-31-1
  • Cat. No. CS-0162322
  • Purity ≥98%
  • MDL No. MFCD16606961
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅Br₂NO
  • Molecular Weight 266.92
  • Synonym(s) (3,6-Dibromo-pyridin-2-yl)-methanol
  • SMILES OCC1=NC(Br)=CC=C1Br

Description

(3,6-Dibromopyridin-2-yl)methanol features a pyridine core functionalized with bromine atoms at the 3 and 6 positions and a methanol group at C2, enabling direct coupling in cross-coupling reactions. The electron-deficient ring facilitates nucleophilic substitution, while the benzylic alcohol offers a handle for derivatization. This scaffold integrates readily into complex heterocyclic systems under standard conditions.

Application

(3,6-Dibromopyridin-2-yl)methanol serves as a versatile building block for the synthesis of brominated pyridine scaffolds, enabling efficient late-stage functionalization in medicinal chemistry. The pendant hydroxymethyl group facilitates derivatization via oxidation or substitution reactions, while the dibromo substitution pattern supports palladium-catalyzed cross-coupling processes. Its bench-stable solid form and compatibility with standard reaction conditions make it suitable for scalable synthesis and modular library construction.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   33.12
  • LogP   2.0989
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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