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CS-W001157 4
Total: USD 88.00

2-Chloro-3-methoxypyridin-4-amine

  • CAS No. 1227600-23-8

  • Cat. No. CS-0148313
  • Molecule weight158.59
  • Purity≥96%
  • MDL No.MFCD11553128

*For research and further manufacturing use only, not for direct human use.

2-Chloro-3-methoxypyridin-4-amine|CS-0148313

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General Information

  • CAS No. 1227600-23-8
  • Cat. No. CS-0148313
  • Purity ≥96%
  • MDL No. MFCD11553128
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇ClN₂O
  • Molecular Weight 158.59
  • Synonym(s) 4-Pyridinamine, 2-chloro-3-methoxy-
  • SMILES ClC1=NC=CC(N)=C1OC

Description

2-Chloro-3-methoxypyridin-4-amine features a pyridine core bearing chlorine and methoxy substituents at adjacent positions, enabling selective coupling reactions. The amine functionality provides a reactive handle for diversification in medicinal chemistry applications. This compound serves as a key intermediate in the synthesis of bioactive heterocycles and agrochemicals.

Application

2-Chloro-3-methoxypyridin-4-amine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its reactive chloropyridine moiety. The methoxy and amino groups provide orthogonal functional handles for sequential derivatization, while the compound exhibits excellent bench stability and compatibility with standard purification methods.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

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Computational Chemistry Data

  • TPSA   48.14
  • LogP   1.3258
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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