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6-Chloro-2-fluoropyridin-3-amine

  • CAS No. 1227600-05-6

  • Cat. No. CS-0169777
  • Molecule weight146.55
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

6-Chloro-2-fluoropyridin-3-amine|CS-0169777

Structure of 1227600-05-6

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General Information

  • CAS No. 1227600-05-6
  • Cat. No. CS-0169777
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₄ClFN₂
  • Molecular Weight 146.55
  • Synonym(s) 6-Chloro-2-fluoro-3-pyridinamine
  • SMILES ClC1=NC(F)=C(N)C=C1

Description

6-Chloro-2-fluoropyridin-3-amine features a trifunctional pyridine core with electron-withdrawing chlorine and fluorine substituents positioned for orthogonal reactivity. This bench-stable scaffold integrates readily into heterocyclic syntheses, enabling efficient access to advanced intermediates in medicinal chemistry and agrochemical development.

Application

6-Chloro-2-fluoropyridin-3-amine serves as a versatile building block in medicinal chemistry, enabling efficient access to functionalized pyridine scaffolds. Its orthogonal halogenation pattern facilitates palladium-catalyzed cross-coupling reactions, while the amine group supports direct derivatization via acylation, alkylation, or reductive amination. The compound exhibits good bench stability and is compatible with standard purification methods, making it well-suited for iterative synthesis workflows in API development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

Quality Control

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   1.4563
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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