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CS-W001157 4
Total: USD 88.00

4-Bromo-2,3-difluoropyridine

  • CAS No. 1227597-53-6

  • Cat. No. CS-0443061
  • Purity≥98%
  • MDL No.MFCD16609910

*For research and further manufacturing use only, not for direct human use.

4-Bromo-2,3-difluoropyridine|CS-0443061

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General Information

  • CAS No. 1227597-53-6
  • Cat. No. CS-0443061
  • Purity ≥98%
  • MDL No. MFCD16609910
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₂BrF₂N
  • Molecular Weight 193.98
  • Synonym(s) None
  • SMILES C1=CN=C(C(=C1Br)F)F

Description

4-Bromo-2,3-difluoropyridine is a fluorinated heterocyclic building block featuring complementary halogen handles for cross-coupling reactions. The electron-deficient pyridine core enables efficient palladium-catalyzed transformations, while the difluoro substitution enhances metabolic stability and modulates electronic properties in pharmaceutical intermediates.

Application

4-Bromo-2,3-difluoropyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its reactive bromine and electron-deficient pyridine core. The ortho-fluorine substituents enhance metabolic stability and facilitate directed metalation. Its bench-stable nature and compatibility with diverse functional groups make it ideal for constructing complex heterocyclic scaffolds in API development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.1223
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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