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CS-W001157 4
Total: USD 88.00

4-Methoxy-5-(trifluoromethyl)pyridin-2-amine

  • CAS No. 1227571-99-4

  • Cat. No. CS-0043149
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-Methoxy-5-(trifluoromethyl)pyridin-2-amine|CS-0043149

Structure of 1227571-99-4

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General Information

  • CAS No. 1227571-99-4
  • Cat. No. CS-0043149
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇F₃N₂O
  • Molecular Weight 192.14
  • Synonym(s) None
  • SMILES FC(C1=CN=C(N)C=C1OC)(F)F

Description

4-Methoxy-5-(trifluoromethyl)pyridin-2-amine features a trifluoromethyl group enhancing electron-withdrawal and metabolic stability, paired with a methoxy substituent that improves solubility and modulates electronic properties. This combination delivers a robust scaffold for medicinal chemistry applications, particularly in kinase inhibitor design and bioactive heterocycle synthesis.

Application

4-Methoxy-5-(trifluoromethyl)pyridin-2-amine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles via palladium-catalyzed cross-coupling and electrophilic substitution reactions. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the methoxy and amine functionalities offer orthogonal handles for further derivatization. The compound exhibits excellent bench stability and is readily purified by column chromatography, making it well-suited for scalable synthesis workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   48.14
  • LogP   1.6912
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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