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Structure of 1227571-99-4
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4-Methoxy-5-(trifluoromethyl)pyridin-2-amine features a trifluoromethyl group enhancing electron-withdrawal and metabolic stability, paired with a methoxy substituent that improves solubility and modulates electronic properties. This combination delivers a robust scaffold for medicinal chemistry applications, particularly in kinase inhibitor design and bioactive heterocycle synthesis.
4-Methoxy-5-(trifluoromethyl)pyridin-2-amine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles via palladium-catalyzed cross-coupling and electrophilic substitution reactions. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the methoxy and amine functionalities offer orthogonal handles for further derivatization. The compound exhibits excellent bench stability and is readily purified by column chromatography, making it well-suited for scalable synthesis workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H319
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: