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CS-W001157 4
Total: USD 88.00

5-BROMO-2-HYDROXYISONICOTINALDEHYDE

  • CAS No. 1227562-37-9

  • Cat. No. CS-W000635
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-BROMO-2-HYDROXYISONICOTINALDEHYDE|CS-W000635

Structure of 1227562-37-9

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General Information

  • CAS No. 1227562-37-9
  • Cat. No. CS-W000635
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄BrNO₂
  • Molecular Weight 202.01
  • Synonym(s) None
  • SMILES O=Cc1cc(O)ncc1Br

Description

5-Bromo-2-hydroxyisonicotinaldehyde features a strategically positioned bromine atom and a reactive aldehyde group flanked by a hydroxyl moiety, enabling direct incorporation into heterocyclic scaffolds. This electron-deficient pyridine derivative facilitates efficient coupling reactions under mild conditions, offering high functional group tolerance and enhanced solubility in polar aprotic solvents.

Application

5-Bromo-2-hydroxyisonicotinaldehyde serves as a versatile building block in synthetic organic chemistry, enabling efficient access to substituted heterocycles and bioactive scaffolds. Its ortho-hydroxy aldehyde functionality facilitates intramolecular cyclizations and metal-catalyzed coupling reactions, while the bromine substituent supports further functionalization via palladium-mediated transformations. The compound exhibits bench stability and compatibility with common protecting group strategies, making it well-suited for iterative synthesis in medicinal chemistry and process development workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P261-P280-P304+P340

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.3622
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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