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CS-W001157 4
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5-Bromo-3-(bromomethyl)-2-methoxypyridine

  • CAS No. 1227516-75-7

  • Cat. No. CS-0527033
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Bromo-3-(bromomethyl)-2-methoxypyridine|CS-0527033

Structure of 1227516-75-7

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General Information

  • CAS No. 1227516-75-7
  • Cat. No. CS-0527033
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇Br₂NO
  • Molecular Weight 280.94
  • Synonym(s) None
  • SMILES COC1=NC=C(Br)C=C1CBr

Description

5-Bromo-3-(bromomethyl)-2-methoxypyridine features a reactive bromomethyl group flanked by electron-withdrawing bromine and methoxy substituents, enabling selective functionalization in cross-coupling and nucleophilic substitution reactions. This bench-stable pyridine derivative integrates readily into complex molecular architectures under standard conditions.

Application

5-Bromo-3-(bromomethyl)-2-methoxypyridine serves as a versatile bifunctional building block in medicinal chemistry and cross-coupling synthesis. The bromomethyl group enables efficient alkylation or Suzuki-Miyaura coupling, while the C5-bromo substituent supports palladium-catalyzed transformations. Its bench-stable nature and orthogonal reactivity facilitate modular construction of complex heterocyclic scaffolds, particularly in kinase inhibitor and API development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅱ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Computational Chemistry Data

  • TPSA   22.12
  • LogP   2.7476
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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