3-(2-Chloro-10H-phenothiazin-10-yl)-N-methylpropan-1-amine

Name: 3-(2-Chloro-10H-phenothiazin-10-yl)-N-methylpropan-1-amine
Brand: ChemScene
Availability: OutOfStock
Rating: 5 (1 reviews)

CAS No. 1225-64-5
Cat. No. CS-0571112
Molecule weight304.84
Purity≥98%
MDL No.MFCD22666252

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

3-(2-Chloro-10H-phenothiazin-10-yl)-N-methylpropan-1-amine|CS-0571112

Structure of 1225-64-5

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 1225-64-5
Cat. No. CS-0571112
Purity ≥98%
MDL No. MFCD22666252
Storage Sealed in dry,2-8℃
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₆H₁₇ClN₂S
Molecular Weight 304.84
Synonym(s) Norchlorpromazine
SMILES CNCCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl

Description

A cell-permeable 3-substituted indolinone compound that displays anti-proliferative and proapoptotic properties in tumor cells. Acts as a potent, selective, reversible, and ATP-competitive inhibitor of cyclin dependent kinases (Cdks; IC50 = 22 nM for Cdk2/A; 40 nM for Cdk1/B; 200 nM for Cdk4/D1). It shows no significant effect (IC50 >10 M) on the activities of PKC, p38, PDGFR, or EGFR. Inhibits the proliferation of growth factor-stimulated colon carcinoma cells by binding to Cdk2 and preventing the phosphorylation of pRb and its dissociation from E2F.

Synthesis

Route1
- In-stock
  
  50-53-3
- ~%
- 1225-64-5
References
- Kigondu, Elizabeth M.; Njoroge, Mathew; Singh, Kawaljit; Njuguna, Nicholas; Warner, Digby F.; Chibale, Kelly MedChemComm, 2014 , vol. 5, # 4 p. 502 - 506
Route2
- 92-39-7
- ~%
- 1225-64-5
References
- Fujii Yakugaku Zasshi, 1956 , vol. 76, p. 644,647, 648 Chem.Abstr., 1957 , p. 425
Route3
- 4414-83-9
- ~%
- 1225-64-5
References
- Fujii Yakugaku Zasshi, 1956 , vol. 76, p. 644,647, 648 Chem.Abstr., 1957 , p. 425

Safety Information

Download SDS

GHS Pictogram : N/A	GHS No : N/A
Signal Word : N/A	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : N/A
Precautionary Statements : N/A

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 15.27
LogP 4.5522
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 4

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Other aromatic heterocycles compounds

Key Words

1225-64-5 sigma1225-64-5 manufacturer1225-64-5 price1225-64-5 structure1225-64-5 SDSbuy 1225-64-51225-64-5 supplier1225-64-5 uses1225-64-5 molecular weightprice of 1225-64-51225-64-5 chemical name formula of 1225-64-5

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

3-(2-Chloro-10H-phenothiazin-10-yl)-N-methylpropan-1-amine

CAS No. 1225-64-5

Recommended Products

General Information

Description

Synthesis

References

References

References

Safety Information

Quality Control

Computational Chemistry Data

Similar Products

Other Classifications

Recently Viewed Products

Key Words