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CS-W001157 4
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5-Oxo-4,5-dihydropyrazolo[1,5-a]pyrimidine-3-carboxylic acid

  • CAS No. 1224944-46-0

  • Cat. No. CS-W000742
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Oxo-4,5-dihydropyrazolo[1,5-a]pyrimidine-3-carboxylic acid|CS-W000742

Structure of 1224944-46-0

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General Information

  • CAS No. 1224944-46-0
  • Cat. No. CS-W000742
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅N₃O₃
  • Molecular Weight 179.13
  • Synonym(s) 5-Oxo-4,5-dihydro-pyrazolo[1,5-a]pyriMidine-3-carboxylic acid
  • SMILES OC(=O)c1cnn2ccc(=O)[nH]c12

Description

This pyrazolo[1,5-a]pyrimidine derivative features a conjugated oxo-carboxylic acid motif enabling direct integration into bioactive scaffolds. The 5-oxo group enhances electrophilicity for nucleophilic addition, while the dihydropyridine ring offers stability under standard conditions. Ideal for medicinal chemistry campaigns requiring electron-deficient heterocycles with defined hydrogen-bonding capacity.

Application

5-Oxo-4,5-dihydropyrazolo[1,5-a]pyrimidine-3-carboxylic acid serves as a versatile heterocyclic building block for medicinal chemistry campaigns, enabling efficient access to pyrazolopyrimidine-based scaffolds. Its carboxylic acid functionality facilitates direct derivatization and conjugation, while the enone system supports Michael addition and nucleophilic substitution reactions. The compound exhibits bench stability and compatibility with standard purification protocols, making it suitable for high-throughput synthesis and structure–activity relationship studies.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Computational Chemistry Data

  • TPSA   87.46
  • LogP   -0.2792
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   1

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