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CS-W001157 4
Total: USD 88.00

8-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)quinolin-2(1H)-one

  • CAS No. 1219130-55-8

  • Cat. No. CS-0369224
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

8-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)quinolin-2(1H)-one|CS-0369224

Structure of 1219130-55-8

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General Information

  • CAS No. 1219130-55-8
  • Cat. No. CS-0369224
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₅H₁₈BNO₃
  • Molecular Weight 271.12
  • Synonym(s) 2-pyridinone-8-boronic ester
  • SMILES O=C1NC2=C(C=CC=C2B3OC(C)(C)C(C)(C)O3)C=C1

Description

This boronate-functionalized quinolinone integrates readily into Suzuki-Miyaura coupling reactions under standard conditions. The tetramethylboronate moiety enhances stability and solubility, enabling efficient cross-coupling with aryl halides. The electron-deficient quinolinone core supports targeted derivatization in medicinal chemistry applications.

Application

8-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)quinolin-2(1H)-one serves as a versatile boronate building block for palladium-catalyzed cross-coupling reactions. Its quinolinone core enables efficient incorporation into biologically relevant scaffolds, while the stable tetramethylborolane group facilitates mild, selective coupling under standard conditions. The compound exhibits excellent bench stability and compatibility with diverse functional groups, simplifying purification and enhancing utility in medicinal chemistry and materials synthesis workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H332
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501

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Computational Chemistry Data

  • TPSA   51.32
  • LogP   1.8273
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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