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CS-W001157 4
Total: USD 88.00

(2-(Benzyloxy)-6-fluorophenyl)boronic acid

  • CAS No. 1217500-53-2

  • Cat. No. CS-0095029
  • Purity≥95%
  • MDL No.MFCD11617256

*For research and further manufacturing use only, not for direct human use.

(2-(Benzyloxy)-6-fluorophenyl)boronic acid|CS-0095029

Structure of 1217500-53-2

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General Information

  • CAS No. 1217500-53-2
  • Cat. No. CS-0095029
  • Purity ≥95%
  • MDL No. MFCD11617256
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₂BFO₃
  • Molecular Weight 246.04
  • Synonym(s) 2-Benzyloxy-6-fluorophenylboronic acid
  • SMILES OB(C1=C(OCC2=CC=CC=C2)C=CC=C1F)O

Description

This boronate moiety integrates a benzyloxy-substituted fluorophenyl scaffold, offering enhanced stability and solubility in polar solvents. The para-fluorine substituent imparts electron-withdrawing character, facilitating efficient Suzuki-Miyaura cross-coupling reactions under standard conditions.

Application

(2-(Benzyloxy)-6-fluorophenyl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient C–C bond formation under mild conditions. The ortho-fluorine substituent enhances regioselectivity and facilitates downstream functionalization, while the benzyloxy group provides stability and orthogonal protection. This reagent exhibits excellent bench stability, tolerates diverse reaction conditions, and simplifies purification—making it ideal for constructing complex aryl scaffolds in medicinal chemistry and materials science applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   49.69
  • LogP   1.0845
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   4

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