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CS-W001157 4
Total: USD 88.00

1-(4-Chloropyridin-2-yl)ethanol

  • CAS No. 121638-26-4

  • Cat. No. CS-0154077
  • Purity≥98%
  • MDL No.MFCD18802690

*For research and further manufacturing use only, not for direct human use.

1-(4-Chloropyridin-2-yl)ethanol|CS-0154077

Structure of 121638-26-4

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General Information

  • CAS No. 121638-26-4
  • Cat. No. CS-0154077
  • Purity ≥98%
  • MDL No. MFCD18802690
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈ClNO
  • Molecular Weight 157.60
  • Synonym(s) 1-(4-Chloro-2-pyridinyl)ethanol
  • SMILES CC(C1=NC=CC(=C1)Cl)O

Description

1-(4-Chloropyridin-2-yl)ethanol features a pyridine ring bearing a chloro substituent at the 4-position and a hydroxymethyl side chain at the 2-position. This configuration imparts enhanced solubility and stability under standard conditions, enabling direct incorporation into synthetic sequences without protection. The molecule serves as a key intermediate in pharmaceutical synthesis, particularly for bioactive heterocycles requiring precise regiocontrol.

Application

1-(4-Chloropyridin-2-yl)ethanol serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyridine-based scaffolds. Its pendant hydroxyl group facilitates derivatization via etherification, esterification, or oxidation to the corresponding aldehyde. The molecule exhibits good bench stability and functional group tolerance, supporting its use in multi-step syntheses. It functions effectively in coupling reactions and heterocycle elaboration, particularly in the development of kinase inhibitors and other bioactive compounds.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   33.12
  • LogP   1.7883
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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