2-Chloro-4-cyclopropyl-6-methylpyrimidine

Name: 2-Chloro-4-cyclopropyl-6-methylpyrimidine
Brand: ChemScene
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CAS No. 121553-38-6
Cat. No. CS-0227173
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-Chloro-4-cyclopropyl-6-methylpyrimidine|CS-0227173

Structure of 121553-38-6

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General Information

CAS No. 121553-38-6
Cat. No. CS-0227173
Purity ≥97%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₉ClN₂
Molecular Weight 168.62
Synonym(s) 2-chloro-4-methyl-6-cyclo-propylpyrimidine
SMILES CC1=CC(C2CC2)=NC(Cl)=N1

Description

2-Chloro-4-cyclopropyl-6-methylpyrimidine features a sterically hindered pyrimidine core with electron-withdrawing chlorine and electron-donating methyl groups, enabling selective reactivity in cross-coupling processes. The cyclopropyl substituent enhances metabolic stability and modulates lipophilicity, making this scaffold valuable for medicinal chemistry applications.

Application

2-Chloro-4-cyclopropyl-6-methylpyrimidine serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyrimidine-based scaffolds. Its chloro group facilitates nucleophilic substitution reactions, while the cyclopropyl and methyl substituents provide steric and electronic modulation. The compound exhibits good bench stability and compatibility with standard coupling protocols, facilitating rapid diversification in target-oriented synthesis.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 25.78
LogP 2.31582
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Building Blocks Skeleton Fatty ring compounds Cyclopropane compounds

Key Words

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2-Chloro-4-cyclopropyl-6-methylpyrimidine

CAS No. 121553-38-6

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