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Structure of 1214367-20-0
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This difluoromethoxy-substituted benzaldehyde features a fluorinated aldehyde handle for direct incorporation into bioactive scaffolds. The para-fluoro group enhances metabolic stability, while the difluoromethoxy moiety imparts electron-withdrawing character and improved lipophilicity. Ideal for medicinal chemistry campaigns requiring tunable electronic and physicochemical properties under standard bench conditions.
3-(Difluoromethoxy)-4-fluorobenzaldehyde serves as a valuable building block in medicinal chemistry, enabling the synthesis of fluorinated aromatic scaffolds. Its aldehyde functionality facilitates efficient reductive amination, Grignard additions, and Ugi-type condensations. The difluoromethoxy and fluoro substituents enhance metabolic stability and modulate lipophilicity, offering favorable properties for drug discovery applications. The compound exhibits good bench stability and is readily purified by silica gel chromatography or recrystallization.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P280-P302+P352
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Lot numbers can be found on the outside label of a product: