3-Bromo-6-(trifluoromethyl)pyridin-2-amine

Name: 3-Bromo-6-(trifluoromethyl)pyridin-2-amine
Brand: ChemScene
Availability: InStock
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CAS No. 1214361-39-3
Cat. No. CS-0060445
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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3-Bromo-6-(trifluoromethyl)pyridin-2-amine|CS-0060445

Structure of 1214361-39-3

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General Information

CAS No. 1214361-39-3
Cat. No. CS-0060445
Purity ≥98%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₄BrF₃N₂
Molecular Weight 241.01
Synonym(s) 3-BROMO-6-(TRIFLUOROMETHYL)PYRIDINE-2-AMINE
SMILES C1=CC(=NC(=C1Br)N)C(F)(F)F

Description

3-Bromo-6-(trifluoromethyl)pyridin-2-amine features a bromine atom at the 3-position and a trifluoromethyl group at the 6-position of a pyridine ring bearing a primary amine at the 2-position. This electron-deficient heterocycle enables direct functionalization in cross-coupling reactions, serving as a key scaffold for pharmaceutical intermediates and advanced ligands.

Application

3-Bromo-6-(trifluoromethyl)pyridin-2-amine serves as a versatile building block for constructing bioactive heterocycles, enabling palladium-catalyzed cross-coupling reactions with broad functional group tolerance. The bromo and amino groups provide orthogonal reactivity for sequential modifications, while the trifluoromethyl substituent enhances metabolic stability and lipophilicity—key attributes in medicinal chemistry. Its bench-stable crystalline form facilitates handling and purification, making it well-suited for scalable synthesis of pharmaceutical intermediates and kinase inhibitor scaffolds.

Synthesis

Route1
- In-stock
  
  34486-24-3
- ~23%
- In-stock
  
  1214361-39-3
References
- Baumann, Karlheinz; Flohr, Alexander; Goetschi, Erwin; Green, Luke; Jolidon, Synese; Knust, Henner; Limberg, Anja; Luebbers, Thomas; Thomas, Andrew Patent: US2011/201605 A1, 2011 ; Location in patent: Page/Page column 56 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

TPSA 38.91
LogP 2.4451
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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3-Bromo-6-(trifluoromethyl)pyridin-2-amine

CAS No. 1214361-39-3

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