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CS-W001157 4
Total: USD 88.00

4-(Difluoromethoxy)-2-fluorobenzaldehyde

  • CAS No. 1214358-05-0

  • Cat. No. CS-0455172
  • Molecule weight190.12
  • Purity≥97%
  • MDL No.MFCD11847162

*For research and further manufacturing use only, not for direct human use.

4-(Difluoromethoxy)-2-fluorobenzaldehyde|CS-0455172

Structure of 1214358-05-0

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General Information

  • CAS No. 1214358-05-0
  • Cat. No. CS-0455172
  • Purity ≥97%
  • MDL No. MFCD11847162
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅F₃O₂
  • Molecular Weight 190.12
  • Synonym(s) None
  • SMILES C1=CC(=CC(=C1C=O)F)OC(F)F

Description

4-(Difluoromethoxy)-2-fluorobenzaldehyde features a strategically positioned aldehyde group flanked by electron-withdrawing fluorine and difluoromethoxy substituents, enhancing reactivity in cross-coupling and electrophilic substitution reactions. This bench-stable aromatic aldehyde integrates readily into complex molecular architectures requiring precise electronic tuning.

Application

4-(Difluoromethoxy)-2-fluorobenzaldehyde serves as a versatile building block in medicinal chemistry, enabling the construction of fluorinated aromatic scaffolds via standard coupling reactions. Its ortho-fluoro and difluoromethoxy substituents provide enhanced metabolic stability and modulated electronic properties. The aldehyde functionality facilitates efficient derivatization through reductive amination, Grignard additions, or condensation reactions, offering reliable access to complex target molecules with high functional group tolerance and bench stability.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.3
  • LogP   2.2396
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   3

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