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CS-W001157 4
Total: USD 88.00

5-Chloro-2-(difluoromethoxy)pyridine

  • CAS No. 1214323-40-6

  • Cat. No. CS-0107232
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Chloro-2-(difluoromethoxy)pyridine|CS-0107232

Structure of 1214323-40-6

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General Information

  • CAS No. 1214323-40-6
  • Cat. No. CS-0107232
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄ClF₂NO
  • Molecular Weight 179.55
  • Synonym(s) None
  • SMILES FC(F)OC1=NC=C(Cl)C=C1

Description

5-Chloro-2-(difluoromethoxy)pyridine features a difluoromethoxy group at the 2-position, enhancing electron-withdrawal and metabolic stability. The chloro substituent at the 5-position enables selective functionalization in late-stage derivatization. This pyridine scaffold integrates readily into bioactive molecules, offering favorable solubility and compatibility with common coupling reactions under standard conditions.

Application

5-Chloro-2-(difluoromethoxy)pyridine serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the C5 position via palladium-catalyzed cross-coupling reactions. The difluoromethoxy group enhances metabolic stability and modulates lipophilicity, while the chloropyridine moiety supports orthogonal reactivity in heterocyclic synthesis. This compound exhibits excellent bench stability and facilitates efficient incorporation into API scaffolds through standard coupling protocols.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H320-H335
Precautionary Statements : P264-P270-P330

Quality Control

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Computational Chemistry Data

  • TPSA   22.12
  • LogP   2.3364
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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