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Structure of 1211591-88-6
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5-(Trifluoromethyl)pyridazin-3-amine features a trifluoromethyl group at the 5-position, enhancing electron deficiency and metabolic stability. This nitrogen-rich heterocycle integrates readily into medicinal chemistry scaffolds, offering improved solubility and target engagement in kinase inhibitor development.
5-(Trifluoromethyl)pyridazin-3-amine serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles through standard coupling reactions. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the pyridazinamine core provides a reactive site for Suzuki-Miyaura, Ullmann, or amide bond formation. The compound exhibits good bench stability and facilitates efficient purification, making it well-suited for iterative synthesis campaigns in API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: