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CS-W001157 4
Total: USD 88.00

5-(Trifluoromethyl)pyridazin-3-amine

  • CAS No. 1211591-88-6

  • Cat. No. CS-W022265
  • Purity≥97%
  • MDL No.MFCD20726836

*For research and further manufacturing use only, not for direct human use.

5-(Trifluoromethyl)pyridazin-3-amine|CS-W022265

Structure of 1211591-88-6

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General Information

  • CAS No. 1211591-88-6
  • Cat. No. CS-W022265
  • Purity ≥97%
  • MDL No. MFCD20726836
  • Storage -20°C, sealed storage, away from moisture and light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₄F₃N₃
  • Molecular Weight None
  • Synonym(s) 5-Trifluoromethyl-pyridazin-3-ylamine
  • SMILES NC1=NN=CC(C(F)(F)F)=C1

Description

5-(Trifluoromethyl)pyridazin-3-amine features a trifluoromethyl group at the 5-position, enhancing electron deficiency and metabolic stability. This nitrogen-rich heterocycle integrates readily into medicinal chemistry scaffolds, offering improved solubility and target engagement in kinase inhibitor development.

Application

5-(Trifluoromethyl)pyridazin-3-amine serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles through standard coupling reactions. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the pyridazinamine core provides a reactive site for Suzuki-Miyaura, Ullmann, or amide bond formation. The compound exhibits good bench stability and facilitates efficient purification, making it well-suited for iterative synthesis campaigns in API development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   51.8
  • LogP   1.0776
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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