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CS-W001157 4
Total: USD 88.00

6-Bromo-4-chloropyridin-3-ol

  • CAS No. 1211584-86-9

  • Cat. No. CS-0568526
  • Purity≥95%
  • MDL No.MFCD18257592

*For research and further manufacturing use only, not for direct human use.

6-Bromo-4-chloropyridin-3-ol|CS-0568526

Structure of 1211584-86-9

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General Information

  • CAS No. 1211584-86-9
  • Cat. No. CS-0568526
  • Purity ≥95%
  • MDL No. MFCD18257592
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃BrClNO
  • Molecular Weight None
  • Synonym(s) None
  • SMILES OC1=C(Cl)C=C(Br)N=C1

Description

6-Bromo-4-chloropyridin-3-ol features a pyridinol core with bromo and chloro substituents at the 6- and 4-positions, respectively, enabling selective functionalization in medicinal chemistry. The hydroxyl group enhances solubility and serves as a handle for derivatization. This compound is bench-stable and compatible with standard cross-coupling protocols.

Application

6-Bromo-4-chloropyridin-3-ol serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen functionality. The bromo group facilitates Suzuki, Stille, or Negishi coupling, while the chloro and hydroxyl groups offer complementary reactivity for further derivatization. Its bench-stable nature and compatibility with standard purification methods support efficient synthesis of heterocyclic scaffolds and API intermediates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   33.12
  • LogP   2.2031
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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