Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

2-(Difluoromethoxy)isonicotinic acid

  • CAS No. 1211581-51-9

  • Cat. No. CS-0136259
  • Purity≥98%
  • MDL No.MFCD18258474

*For research and further manufacturing use only, not for direct human use.

2-(Difluoromethoxy)isonicotinic acid|CS-0136259

Structure of 1211581-51-9

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 1211581-51-9
  • Cat. No. CS-0136259
  • Purity ≥98%
  • MDL No. MFCD18258474
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅F₂NO₃
  • Molecular Weight 189.12
  • Synonym(s) 2-(difluoromethoxy)pyridine-4-carboxylic acid
  • SMILES O=C(O)C1=CC=NC(OC(F)F)=C1

Description

2-(Difluoromethoxy)isonicotinic acid features a para-difluoromethoxy group on an isonicotinic acid scaffold, delivering enhanced lipophilicity and metabolic stability. This electron-withdrawing substitution improves bioavailability in medicinal chemistry applications. The compound serves as a key building block for pharmaceuticals targeting kinase pathways and exhibits robust bench stability under standard conditions.

Application

2-(Difluoromethoxy)isonicotinic acid serves as a versatile building block for bioactive heterocycles and pharmaceutical intermediates, leveraging its ortho-difluoromethoxy-substituted pyridine core. The carboxylic acid functionality enables direct coupling reactions, while the difluoromethoxy group imparts metabolic stability and modulates electronic properties. This compound exhibits excellent bench stability, facilitates straightforward purification, and functions reliably in standard amide, ester, and Suzuki-Miyaura transformations.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   59.42
  • LogP   1.3812
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   3

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 2-(Difluoromethoxy)isonicotinic acid sigma2-(Difluoromethoxy)isonicotinic acid manufacturer2-(Difluoromethoxy)isonicotinic acid price2-(Difluoromethoxy)isonicotinic acid structure2-(Difluoromethoxy)isonicotinic acid SDSbuy 2-(Difluoromethoxy)isonicotinic acid2-(Difluoromethoxy)isonicotinic acid supplier2-(Difluoromethoxy)isonicotinic acid uses2-(Difluoromethoxy)isonicotinic acid molecular weightprice of 2-(Difluoromethoxy)isonicotinic acid2-(Difluoromethoxy)isonicotinic acid chemical name formula of 2-(Difluoromethoxy)isonicotinic acid
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label