5-Fluoro-6-methylpyridin-3-amine

Name: 5-Fluoro-6-methylpyridin-3-amine
Brand: ChemScene
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CAS No. 1211542-12-9
Cat. No. CS-0160707
Molecule weight126.13
Purity≥97%
MDL No.MFCD18250722

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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5-Fluoro-6-methylpyridin-3-amine|CS-0160707

Structure of 1211542-12-9

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General Information

CAS No. 1211542-12-9
Cat. No. CS-0160707
Purity ≥97%
MDL No. MFCD18250722
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₇FN₂
Molecular Weight 126.13
Synonym(s) 5-fluoro-6-methyl-3-Pyridinamine
SMILES NC1=CC(F)=C(C)N=C1

Description

5-Fluoro-6-methylpyridin-3-amine features a strategically positioned fluorine atom and methyl group on the pyridine core, enabling enhanced metabolic stability and tunable electronic properties. This electron-deficient heterocycle integrates readily into pharmaceutical scaffolds, serving as a key building block for kinase inhibitors and bioactive molecules in medicinal chemistry.

Application

5-Fluoro-6-methylpyridin-3-amine serves as a versatile building block in medicinal chemistry, enabling direct incorporation of fluorinated, methylated pyridine motifs into bioactive molecules. Its reactivity profile supports facile coupling reactions, including Suzuki-Miyaura and Buchwald-Hartwig amination, due to the orthogonal functionality of the amine and electron-deficient fluorine. The compound exhibits good bench stability and facilitates efficient purification, making it well-suited for scalable synthesis of kinase inhibitors and other targeted therapeutics.

Synthesis

Route1
- 1253383-92-4
- ~%
- In-stock
  
  1211542-12-9
References
- BOEHRINGER INGELHEIM INTERNATIONAL GMBH; GINN, John David; MARSHALL, Daniel Richard; PROKOPOWICZ, Anthony S.; SCHYLER, Sabine; SIBLEY, Robert; TURNER, Michael Robert; WU, Di; WU, Frank Patent: WO2010/126851 A1, 2010 ; Location in patent: Page/Page column 110 ; WO 2010/126851 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 38.91
LogP 1.11132
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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5-Fluoro-6-methylpyridin-3-amine

CAS No. 1211542-12-9

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