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CS-W001157 4
Total: USD 88.00

3-Bromo-2-(difluoromethyl)pyridine

  • CAS No. 1211520-77-2

  • Cat. No. CS-0134759
  • Purity≥98%
  • MDL No.MFCD16875638

*For research and further manufacturing use only, not for direct human use.

3-Bromo-2-(difluoromethyl)pyridine|CS-0134759

Structure of 1211520-77-2

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General Information

  • CAS No. 1211520-77-2
  • Cat. No. CS-0134759
  • Purity ≥98%
  • MDL No. MFCD16875638
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄BrF₂N
  • Molecular Weight 208.00
  • Synonym(s) None
  • SMILES FC(C1=NC=CC=C1Br)F

Description

3-Bromo-2-(difluoromethyl)pyridine features a strategically positioned difluoromethyl group that enhances metabolic stability and modulates electronic properties. This fluorinated pyridine scaffold integrates readily into medicinal chemistry libraries, offering a valuable handle for cross-coupling reactions and enabling the construction of bioactive molecules with improved pharmacokinetic profiles.

Application

3-Bromo-2-(difluoromethyl)pyridine serves as a versatile building block for the synthesis of fluorinated heterocycles and pharmaceutical intermediates. Its difluoromethyl group imparts enhanced metabolic stability and lipophilicity, while the bromine moiety enables palladium-catalyzed cross-coupling reactions with broad functional group tolerance. The compound exhibits good bench stability and facilitates efficient access to bioactive scaffolds in medicinal chemistry.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.7817
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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