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CS-W001157 4
Total: USD 88.00

2-Bromopyrimidine-4-carboxylic acid

  • CAS No. 1211515-50-2

  • Cat. No. CS-0060693
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Bromopyrimidine-4-carboxylic acid|CS-0060693

Structure of 1211515-50-2

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General Information

  • CAS No. 1211515-50-2
  • Cat. No. CS-0060693
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃BrN₂O₂
  • Molecular Weight 202.99
  • Synonym(s) None
  • SMILES C1=CN=C(Br)N=C1C(=O)O

Description

2-Bromopyrimidine-4-carboxylic acid features a bromine atom at the 2-position and a carboxylic acid group at the 4-position of the pyrimidine ring, enabling selective functionalization in heterocyclic synthesis. This electron-deficient scaffold integrates readily into pharmaceutical intermediates and bioactive molecule frameworks, offering high reactivity under mild coupling conditions.

Application

2-Bromopyrimidine-4-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the C4 position via palladium-catalyzed cross-coupling. Its bromine and carboxylic acid groups offer orthogonal reactivity for late-stage diversification, while the pyrimidine core provides structural rigidity and hydrogen-bonding capacity relevant to target binding. The compound exhibits good bench stability and facilitates efficient purification by crystallization or standard chromatography.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   63.08
  • LogP   0.9373
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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