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CS-W001157 4
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2-Bromo-3-(difluoromethyl)pyridine

  • CAS No. 1211515-00-2

  • Cat. No. CS-0442293
  • Purity≥98%
  • MDL No.MFCD18257230

*For research and further manufacturing use only, not for direct human use.

2-Bromo-3-(difluoromethyl)pyridine|CS-0442293

Structure of 1211515-00-2

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General Information

  • CAS No. 1211515-00-2
  • Cat. No. CS-0442293
  • Purity ≥98%
  • MDL No. MFCD18257230
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄BrF₂N
  • Molecular Weight 208.00
  • Synonym(s) None
  • SMILES C1=CC(=C(Br)N=C1)C(F)F

Description

2-Bromo-3-(difluoromethyl)pyridine features a strategically positioned difluoromethyl group that enhances metabolic stability and modulates electronic properties. This fluorinated pyridine derivative serves as a key building block in medicinal chemistry, enabling direct incorporation of fluorinated motifs into bioactive scaffolds under standard coupling conditions.

Application

2-Bromo-3-(difluoromethyl)pyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions with high functional group tolerance. The difluoromethyl group imparts enhanced metabolic stability and modulates electronic properties, while the bromopyridine moiety facilitates efficient derivatization via Suzuki, Stille, or Negishi couplings. Its bench-stable nature and compatibility with standard reaction conditions make it well-suited for constructing complex heterocyclic scaffolds in API development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.7817
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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