Lot numbers can be found on the outside label of a product:
(2S,4S)-1-tert-butyl 2-methyl 4-aminopyrrolidine-1,2-dicarboxylate
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CAS No. 121148-01-4
- Cat. No. CS-W002842
- Purity≥95%
- MDL No.MFCD01861781
*For research and further manufacturing use only, not for direct human use.
Structure of 121148-01-4
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General Information
- CAS No. 121148-01-4
- Cat. No. CS-W002842
- Purity ≥95%
- MDL No. MFCD01861781
- Storage 4°C, protect from light, stored under nitrogen
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₁H₂₀N₂O₄
- Molecular Weight 244.29
- Synonym(s) 1-(1,1-Dimethylethyl) 2-methyl (2S,4S)-4-amino-1,2-pyrrolidinedicarboxylate
- SMILES COC(=O)[C@@H]1C[C@@H](CN1C(=O)OC(C)(C)C)N
Description
This chiral pyrrolidine derivative features a tert-butyl-protected amine and methyl-substituted backbone, enabling direct incorporation into peptide-like scaffolds. The (2S,4S) stereochemistry ensures high diastereoselectivity in cycloadditions and coupling reactions, while the bench-stable, moisture-tolerant nature simplifies handling under standard conditions.
Application
(2S,4S)-1-tert-butyl 2-methyl 4-aminopyrrolidine-1,2-dicarboxylate serves as a stereochemically defined pyrrolidine building block for medicinal chemistry and peptide-like scaffold synthesis. The protected amine and dicarboxylate groups enable sequential functionalization, while the tert-butyl and methyl substituents provide steric control and bench stability. It facilitates efficient access to chiral heterocycles via standard coupling, reduction, and cyclization protocols in multi-step syntheses.
Synthesis
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Route1
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84520-68-3 - ~96%
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In-stock
121148-01-4
References
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LG LIFE SCIENCES LTD. Patent: WO2010/56022 A2, 2010 ; Location in patent: Page/Page column 22 ; WO 2010/056022 A2
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Route2
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In-stock
74844-91-0 - ~%
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In-stock
121148-01-4
References
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Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 10 p. 2441 - 2445
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Route3
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84520-67-2
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In-stock
121148-01-4
References
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Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 10 p. 2441 - 2445
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 81.86
- LogP 0.4961
- H_Acceptors 5
- H_Donors 1
- Rotatable_Bonds 1
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Key Words
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