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Structure of 1211390-33-8
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3-Cyclopropyl-1H-1,2,4-triazole features a rigid triazole core bearing a cyclopropyl substituent, enhancing its lipophilicity and metabolic stability. This configuration supports integration into bioactive scaffolds, where the heterocyclic ring acts as a hydrogen bond acceptor and π-system for target engagement. The compound exhibits bench-stable handling under standard conditions.
3-Cyclopropyl-1H-1,2,4-triazole serves as a versatile heterocyclic building block in medicinal chemistry, offering enhanced metabolic stability and favorable physicochemical properties. Its cyclopropyl substituent imparts improved lipophilicity and conformational rigidity, enabling efficient incorporation into bioactive scaffolds. The triazole core facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAC) for modular library synthesis and exhibits robust bench stability, ease of purification, and compatibility with diverse functional groups.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: