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CS-W001157 4
Total: USD 88.00

2-(Iodomethyl)oxetane

  • CAS No. 121138-00-9

  • Cat. No. CS-0052227
  • Purity≥95%
  • MDL No.MFCD11226849

*For research and further manufacturing use only, not for direct human use.

2-(Iodomethyl)oxetane|CS-0052227

Structure of 121138-00-9

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General Information

  • CAS No. 121138-00-9
  • Cat. No. CS-0052227
  • Purity ≥95%
  • MDL No. MFCD11226849
  • Storage -20°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₇IO
  • Molecular Weight 198.00
  • Synonym(s) None
  • SMILES ICC1CCO1

Description

2-(Iodomethyl)oxetane is a reactive, bench-stable oxetane derivative featuring a pendant iodomethyl group. This functionality enables efficient coupling reactions in synthetic workflows, particularly in bioconjugation and polymer functionalization. The strained oxetane ring enhances reactivity while maintaining stability under standard conditions.

Application

2-(Iodomethyl)oxetane serves as a versatile electrophilic building block for C–C and C–heteroatom bond formation, enabling efficient functionalization of nucleophiles under mild conditions. Its oxetane ring imparts enhanced metabolic stability and favorable physicochemical properties, making it valuable in medicinal chemistry. The iodomethyl group facilitates palladium-catalyzed couplings and acts as a robust handle for further derivatization. The compound exhibits good bench stability and is compatible with diverse reaction conditions, simplifying purification and integration into complex synthetic sequences.

Synthesis

  • Route1
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    • ~%
    • In-stock
      2-(Iodomethyl)oxetane|CS-0052227
      121138-00-9
    • In-stock
      3-Iodotetrahydrofuran|CS-W004266
      121138-01-0

    References

    • Synthesis, , # 11 p. 862 - 868

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   9.23
  • LogP   1.2103
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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