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CS-W001157 4
Total: USD 88.00

2-Bromo-3-methylpyrazine

  • CAS No. 120984-76-1

  • Cat. No. CS-W021604
  • Purity≥97%
  • MDL No.MFCD08705769

*For research and further manufacturing use only, not for direct human use.

2-Bromo-3-methylpyrazine|CS-W021604

Structure of 120984-76-1

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General Information

  • CAS No. 120984-76-1
  • Cat. No. CS-W021604
  • Purity ≥97%
  • MDL No. MFCD08705769
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₅BrN₂
  • Molecular Weight 173.01
  • Synonym(s) None
  • SMILES CC1=C(Br)N=CC=N1

Description

2-Bromo-3-methylpyrazine is a halogenated heterocyclic compound featuring a pyrazine core with strategically positioned bromo and methyl substituents. This configuration enables direct functionalization in cross-coupling reactions, offering a reliable entry point for synthesizing bioactive analogs and advanced pharmaceutical intermediates under standard conditions.

Application

2-Bromo-3-methylpyrazine serves as a versatile building block in heterocyclic synthesis, enabling palladium-catalyzed cross-coupling reactions to construct biaryl and alkylated pyrazine derivatives. The bromine substituent provides high reactivity in Suzuki, Stille, and Negishi couplings, while the methyl group enhances solubility and modulates electronic properties. Its bench-stable crystalline form facilitates handling and purification, making it well-suited for iterative synthesis in medicinal chemistry and materials science applications.

Synthesis

  • Route1

    References

    • Journal of the American Chemical Society, , vol. 78, p. 2141,2144

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   1.54752
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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