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CS-W001157 4
Total: USD 88.00

4-Bromo-2-(methylsulfonyl)pyridine

  • CAS No. 1209459-93-7

  • Cat. No. CS-0196565
  • Molecule weight236.09
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-Bromo-2-(methylsulfonyl)pyridine|CS-0196565

Structure of 1209459-93-7

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General Information

  • CAS No. 1209459-93-7
  • Cat. No. CS-0196565
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆BrNO₂S
  • Molecular Weight 236.09
  • Synonym(s) 4-Bromo-2-(methylsulphonyl)pyridine
  • SMILES O=S(C1=NC=CC(Br)=C1)(C)=O

Description

4-Bromo-2-(methylsulfonyl)pyridine is a bench-stable, electron-deficient pyridine derivative featuring a bromine at the 4-position and a methylsulfonyl group at the 2-position. This combination enables direct functionalization in cross-coupling reactions and facilitates incorporation into bioactive scaffolds requiring polar, stable substituents.

Application

4-Bromo-2-(methylsulfonyl)pyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its well-defined electrophilic bromide and electron-withdrawing methylsulfonyl group. The molecule exhibits excellent bench stability, facilitates straightforward purification, and supports orthogonal functionalization in the synthesis of heterocyclic scaffolds and API intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H315-H319-H332-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   47.03
  • LogP   1.2476
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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