2-Bromo-3-chloro-1,4-difluorobenzene

Name: 2-Bromo-3-chloro-1,4-difluorobenzene
Brand: ChemScene
Availability: InStock
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CAS No. 1208077-34-2
Cat. No. CS-0098676
Purity≥97%
MDL No.MFCD12922607

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-Bromo-3-chloro-1,4-difluorobenzene|CS-0098676

Structure of 1208077-34-2

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General Information

CAS No. 1208077-34-2
Cat. No. CS-0098676
Purity ≥97%
MDL No. MFCD12922607
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₂BrClF₂
Molecular Weight 227.43
Synonym(s) 1-Bromo-2-chloro-3,6-difluorobenzene
SMILES FC1=C(C(Cl)=C(C=C1)F)Br

Description

2-Bromo-3-chloro-1,4-difluorobenzene features a highly functionalized aromatic core with halogen substituents positioned for orthogonal reactivity. This electron-deficient scaffold enables selective cross-coupling and transition-metal-catalyzed transformations under standard conditions. The strategic placement of bromine, chlorine, and fluorine atoms allows sequential functionalization in complex molecule synthesis. Bench-stable and moisture-tolerant, it serves as a versatile building block for pharmaceutical intermediates and advanced materials.

Application

2-Bromo-3-chloro-1,4-difluorobenzene serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling palladium-catalyzed cross-coupling reactions due to its complementary halogen reactivity profile. The ortho-bromo and meta-chloro substituents provide orthogonal functionalization sites, while the difluoro pattern enhances metabolic stability and modulates electronic properties. Bench-stable and amenable to purification by distillation or chromatography, it facilitates efficient access to complex aromatic scaffolds in multi-step syntheses.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

Quality Control

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Computational Chemistry Data

TPSA 0
LogP 3.3807
H_Acceptors 0
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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2-Bromo-3-chloro-1,4-difluorobenzene

CAS No. 1208077-34-2

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