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CS-W001157 4
Total: USD 88.00

6-Morpholinonicotinic acid

  • CAS No. 120800-52-4

  • Cat. No. CS-W002955
  • Purity≥98%
  • MDL No.MFCD02682034

*For research and further manufacturing use only, not for direct human use.

6-Morpholinonicotinic acid|CS-W002955

Structure of 120800-52-4

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General Information

  • CAS No. 120800-52-4
  • Cat. No. CS-W002955
  • Purity ≥98%
  • MDL No. MFCD02682034
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₂N₂O₃
  • Molecular Weight 208.21
  • Synonym(s) 6-Morpholinopyridine-3-carboxylic acid
  • SMILES OC(=O)c1ccc(nc1)N1CCOCC1

Description

6-Morpholinonicotinic acid delivers a polar morpholino ring fused to a pyridine core, enabling enhanced solubility and metabolic stability in drug discovery. This scaffold integrates readily into bioactive molecules, offering favorable pharmacokinetic profiles and serving as a key building block for kinase inhibitors and CNS-targeted therapeutics.

Application

6-Morpholinonicotinic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its pyridine core with a morpholine substituent at C6 provides enhanced solubility and metabolic stability, while the carboxylic acid group facilitates direct coupling or derivatization. The compound exhibits excellent bench stability and functional group tolerance, making it well-suited for modular synthesis workflows in API development.

Synthesis

  • Route1
    • null|null
      167640-97-3
    • ~%
    • In-stock
      6-Morpholinonicotinic acid|CS-W002955
      120800-52-4

    References

    • US2003/144283 A1, ; US 20030144283 A1
  • Route2
    • null|null
      110-91-8
    • In-stock
      6-Chloronicotinic acid|CS-D1204
      5326-23-8
    • ~%
    • In-stock
      6-Morpholinonicotinic acid|CS-W002955
      120800-52-4

    References

    • US2008/39460 A1, ; Page/Page column 15 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   62.66
  • LogP   0.6164
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   2

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